Endurance exercise training increases medullary and extramedullary hematopoiesis
Bibliographic record
Abstract
Increases in hematocrit are a well known adaptation to exercise training. It is not known if exercise training induces changes in hematopoietic tissues that facilitate increases in hematocrit. The colony forming unit GEMM assay was used to assess the effects of ten weeks of progressive treadmill training on the hematopoietic progenitor content in several tissues of four week old C57Bl/6 mice. Red blood cell progenitors increased by 3.1, 4.7, 2.8, and 1.3 fold (p<0.008 for all) in bone marrow, spleen, blood, and liver, respectively. White blood cell progenitors increased by 1.3 and 3.2 fold (p<0.026 for both) in bone marrow and blood, respectively. Finally, multipotent white and red blood cell progenitors increased by 3.4, 4, and 9.7 fold (p<0.007 for all) in bone marrow, spleen, and blood, respectively. This data indicates that endurance exercise training can increase the hematopoietic progenitor content of bone marrow, blood, spleen, and liver. Increased hematopoiesis in these tissues may help facilitate endurance training associated increases in hematocrit.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".