Endurance exercise training increases medullary and extramedullary hematopoiesis
Bibliographic record
Abstract
Increases in hematocrit are a well known adaptation to exercise training. It is not known if exercise training induces changes in hematopoietic tissues that facilitate increases in hematocrit. The colony forming unit GEMM assay was used to assess the effects of ten weeks of progressive treadmill training on the hematopoietic progenitor content in several tissues of four week old C57Bl/6 mice. Red blood cell progenitors increased by 3.1, 4.7, 2.8, and 1.3 fold (p<0.008 for all) in bone marrow, spleen, blood, and liver, respectively. White blood cell progenitors increased by 1.3 and 3.2 fold (p<0.026 for both) in bone marrow and blood, respectively. Finally, multipotent white and red blood cell progenitors increased by 3.4, 4, and 9.7 fold (p<0.007 for all) in bone marrow, spleen, and blood, respectively. This data indicates that endurance exercise training can increase the hematopoietic progenitor content of bone marrow, blood, spleen, and liver. Increased hematopoiesis in these tissues may help facilitate endurance training associated increases in hematocrit.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".