Stability of clonidine suspension in oral plastic syringes
Bibliographic record
Abstract
PURPOSE: The stability of clonidine suspensions stored at room temperature and under refrigeration for three months was evaluated. METHODS: Oral suspensions of clonidine 0.01 mg/mL were prepared in Ora-Blend and stored in clear plastic syringes at 25 °C and 4 °C. Samples were collected from each syringe at the time of preparation, at weekly intervals for up to 28 days, and on days 42, 56, 77, and 91. Changes in color, taste, and pH, as well as visual evidence of precipitation, were used to determine physical compatibility. Immediately after the physical observations were made, 1.5-mL samples from each syringe were transferred to polypropylene freezer vials and stored at -85 °C until high-performance liquid chromatographic (HPLC) analysis. The samples were analyzed by a validated stability-indicating HPLC-ultraviolet-light detection method. Stability was defined as the retention of at least 90% of the initial clonidine concentration. The precision of the assay was evaluated by intraday and interday validation methods. RESULTS: Clonidine suspensions stored at 25 °C and 4 °C maintained 99.2% and 99.0% of the initial concentration for 91 days, respectively. No interfering peaks were generated by forced degradation of clonidine with heat, hydrochloric acid, sodium hydroxide, or hydrogen peroxide There were no notable changes in pH, and all samples remained physically unchanged during the study period. CONCLUSION: An extemporaneously prepared suspension of clonidine 0.01 mg/mL in Ora-Blend was stable for at least 91 days when stored in clear plastic syringes at either 25 °C or 4 °C.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".