Change in the V/B Polymorph Ratio and T1 Relaxation of Epichlorohydrin Crosslinked High Amylose Starch Excipient
Bibliographic record
Abstract
High amylose epichlorohydrin crosslinked starch excipient was examined to gain understanding of the starch polymorph changes as the crosslinking degree (CLD) increases. When the crosslinking degree is high, the sample is mostly amorphous, and the V/B ratio decreased. For this sample, “humidification” or “water soaking”, cannot overcome crystallization restraint due to the high crosslinking degree. The water soaked 20% CLD sample show some sharp, low intensity double helix 13C resonances. This sample is paracrystalline as can be seen from the collapse of the C(1) doublet to a singlet. Relaxation studies show that increasing crosslinking degree increases the amorphous content. It is also suggested that crosslinking is not homogeneous and that it is concentrated in the non-crystalline domain. A correlation was found between the decrease in content of B-type material and drug release kinetics. With increasing CLD, the reduction in crystalline order increases mobility, however, increasing covalent bonds in the excipient matrix reduces mobility. Differences in relaxation rate of the several overlapping resonances in the 70—80 ppm range of the 13C spectrum are pronounced and allow tentative bond assignments.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".