Change in the V/B Polymorph Ratio and T1 Relaxation of Epichlorohydrin Crosslinked High Amylose Starch Excipient
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
High amylose epichlorohydrin crosslinked starch excipient was examined to gain understanding of the starch polymorph changes as the crosslinking degree (CLD) increases. When the crosslinking degree is high, the sample is mostly amorphous, and the V/B ratio decreased. For this sample, “humidification” or “water soaking”, cannot overcome crystallization restraint due to the high crosslinking degree. The water soaked 20% CLD sample show some sharp, low intensity double helix 13C resonances. This sample is paracrystalline as can be seen from the collapse of the C(1) doublet to a singlet. Relaxation studies show that increasing crosslinking degree increases the amorphous content. It is also suggested that crosslinking is not homogeneous and that it is concentrated in the non-crystalline domain. A correlation was found between the decrease in content of B-type material and drug release kinetics. With increasing CLD, the reduction in crystalline order increases mobility, however, increasing covalent bonds in the excipient matrix reduces mobility. Differences in relaxation rate of the several overlapping resonances in the 70—80 ppm range of the 13C spectrum are pronounced and allow tentative bond assignments.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it