Nuclear Trafficking of the G-Protein−Coupled Parathyroid Hormone Receptor
Bibliographic record
Abstract
G-protein-coupled receptors are a family of receptors that signal primarily through heterotrimeric G proteins. However, new evidence has emerged to show that the signaling capabilities of the receptors are beyond those of traditional signaling cascades. One such example is that the parathyroid hormone (PTH) type 1 receptor is found not only at the plasma membrane but also in the nucleus of cells in cell lines and tissues. This review discusses the emerging concepts of nuclear PTH signaling and relates this information to the growing field of nuclear G-protein-coupled receptors. We review recently published studies on the mechanism of PTH nuclear localization, its role in the cell nucleus, and the contrasting roles ligands play in regulating the receptors' nuclear localization. The review also discusses the importance of nuclear G-protein-coupled receptors and future directions for research in this field.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".