Comparison of the Effects of an Alcoholic St. John's Wort Extract on Various Isolated Organs
Bibliographic record
Abstract
We have studied the effects of a St. John's wort extract used in therapy on contractions of various isolated organ preparations induced by diverse spasmogens. Although it nonspecifically antagonized guinea pig ileum contractions induced by 7 different spasmogens, it had no effect on depolarization-induced contractions of rat aorta or those induced by acetylcholine, histamine or serotonin in the guinea-pig trachea. Spontaneous rhythmic contractions of rat portal veins were also not affected by the extract. Serotonin-induced contractions of rat aorta were most effectively inhibited by the agent. The observed effects of the extract were more prominent after it was washed out of the organ bath. Surprisingly, however, the extract also exerted negative inotropic and chronotropic effects on the rat atrium preparation. Our observations revealed several pharmacological properties of the Hypericum extract, and thus could be helpful in identifying and characterizing its active components and their modes of action.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".