Successful Treatment of Refractory Aquagenic Pruritus with Naltrexone
Bibliographic record
Abstract
Aquagenic pruritus is an intense prickling sensation that develops in affected individuals immediately after contact with water at any temperature. It is most commonly associated with polycythemia rubra vera. Common but often ineffective treatments include anticholinergics and antihistamines. Other moderately successful treatments include capsaicin cream, UVB phototherapy, and sodium bicarbonate bath water. In this case report we describe a 55-year-old female with severe itching following showers. Underlying causes were ruled out with a series of blood tests, a chest X-ray, and serum protein electrophoresis. After multiple treatment failures, her itching was relieved with naltrexone. Endogenous opiates, like naltrexone, can modify pruritus by influencing the peripheral and central sensation of itch. It has been found to be successful in suppressing the perception of pruritus from many diverse origins including aquagenic pruritus. Aquagenic pruritus est une sensation intense de picotement qui apparaît immédiatement après le contact avec 1’eau, peu importe sa température. Elle est fréquemment associée à la polycythémie vraie. Les traitements courants, mais souvent inefficaces, comprennent les anticholinergiques et les antihistaminiques. D’autres traitements à succès modéré comprennent les crèmes de capsicine, la photothérapie aux rayons UV et les bains au bicarbonate de soude. Le présent rapport de cas décrit la situation d’une femme âgée de 55 ans qui souffre de démangeaison aiguë après les douches. Une série de prélèvements sanguins, des radiographies pulmonaires et des électrophorèses des protéines sériques ont permis d’éliminer les causes sous-jacentes possibles. Après l’échec de multiples traitements, sa démangeaison a été soignée grâce au naltrexone. Les agents endogènes opiacés, tels que naltrexone, peuvent modifier le prurit en agissant sur la sensation centrale et périphérique de démangeaison. Ce traitement semble efficace sur toute sorte de prurit, y compris le prurit lié à 1’eau.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".