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Record W2068162513 · doi:10.1038/ng.2238

Common variants at 12q15 and 12q24 are associated with infant head circumference

2012· review· en· W2068162513 on OpenAlexafffund
H. Rob Taal, Beaté St Pourcain, Elisabeth Thiering, Shikta Das, Dennis O. Mook‐Kanamori, Nicole M. Warrington, Marika Kaakinen, Eskil Kreiner‐Møller, Jonathan P. Bradfield, Rachel M. Freathy, Frank Geller, Mònica Guxens, Diana L. Cousminer, Marjan Kerkhof, Nicholas J. Timpson, M. Arfan Ikram, Lawrence J. Beilin, Klaus Bønnelykke, Jessica L. Buxton, Pimphen Charoen, Bo Chawes, Johan G. Eriksson, David M. Evans, Albert Hofman, John P. Kemp, Cecilia E. Kim, Norman Klopp, Jari Lahti, Stephen J. Lye, George McMahon, Frank Mentch, Martina Müller‐Nurasyid, Paul F. O’Reilly, Inga Prokopenko, Fernando Rivadeneira, Eric A.P. Steegers, Jordi Sunyer, Carla M. T. Tiesler, Hanieh Yaghootkar, Monique M.B. Breteler, Stéphanie Debette, Myriam Fornage, Vilmundur Guðnason, Lenore J. Launer, Aad van der Lugt, Thomas H. Mosley, Sudha Seshadri, Albert V. Smith, Meike W. Vernooij, Alexandra I. F. Blakemore, Rosetta Chiavacci, Bjarke Feenstra, Julio Fernandez-Banet, Struan F.A. Grant, Anna‐Liisa Hartikainen, Albert J. van der Heijden, Carmen Íñiguez, Mark Lathrop, Wendy L. McArdle, Anne Mølgaard, John P. Newnham, Lyle J. Palmer, Aarno Palotie, A. Pouta, Susan M. Ring, Ulla Sovio, Marie Standl, André G. Uitterlinden, H-Erich Wichmann, Nadja Hawwa Vissing, Charles DeCarli, Cornelia M. van Duijn, Mark I. McCarthy, Gerard H. Koppelman, Xavier Estivill, Andrew T. Hattersley, Mads Melbye, Hans Bisgaard, Craig E. Pennell, Elisabeth Widén, Håkon Håkonarson, George Davey Smith, Joachim Heinrich, Marjo‐Riitta Järvelin, Vincent W. V. Jaddoe

Bibliographic record

VenueNature Genetics · 2012
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsLunenfeld-Tanenbaum Research InstituteOntario Institute for Cancer ResearchUniversity of TorontoMount Sinai Hospital
FundersNational Institute of Mental HealthNational Heart, Lung, and Blood InstituteBiocenter, University of OuluHelmholtz Zentrum MünchenInstituto de Salud Carlos IIINational Health and Medical Research CouncilMedical Research CouncilCanadian Institutes of Health ResearchNational Institute for Health and Care ResearchGentofte HospitalWeill Cornell Medical CollegeNederlandse Organisatie voor Wetenschappelijk OnderzoekCenters for Disease Control and PreventionUniversity of TorontoOulun YliopistoStatens Serum InstitutUniversity of BristolNierstichtingUniversitair Medisch Centrum GroningenErasmus Universiteit RotterdamNational Institutes of HealthRijksuniversiteit GroningenEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentZonMwUniversity of ExeterRaine Medical Research FoundationErasmus Medisch CentrumBritish Heart FoundationWellcome TrustSchool of Public Health, Imperial College LondonFundació la Marató de TV3Imperial College LondonChildren's Hospital of PhiladelphiaHelsingin Yliopisto
KeywordsGenome-wide association studyBiologyHead circumferenceSingle-nucleotide polymorphismGeneticsCircumferenceGenetic associationChromosomePregnancyGenotypeBirth weightGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.003
Threshold uncertainty score0.007

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0020.002
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.032
GPT teacher head0.320
Teacher spread0.287 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations143
Published2012
Admission routes2
Has abstractno

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