Angle closure glaucoma associated with venlafaxine treatment
Bibliographic record
Abstract
Abstract Purpose Despite its very weak anticholinergic profile, there are few case reports linking venlafaxine treatment with angle closure glaucoma. One of the principal pathophysiological mechanisms suggested is through supraciliary effusions. Methods We report a case of an 86 year old patient who presented with progressive symptoms of angle closure glaucoma in her left eye. Venlafaxine treatment had been started one week prior to presentation. Intraocular pressures were initially 22 mmHg in the right eye and 59 mmHg in the left eye. Ultrasound biomicroscopy (UBM) and gonioscopic exams were performed to better identify the pathophysiologic mechanism of her glaucoma. Results Gonioscopy demonstrated a closed angle in the left eye and a narrow angle in the right eye. Venlafaxine was discontinued and an anti‐glaucomatous treatment was started. There was bilateral resistance to 2% pilocarpine at presentation which subsided 48 hours after venlafaxine cessation. UBM demonstrated a plateau iris configuration with absence of supraciliary effusions. Conclusion To our knowledge, this is the first case describing angle closure glaucoma associated with venlafaxine treatment, where there is a documented bilateral resistance to pilocarpine and an UBM demonstrating a plateau iris configuration with absence of ciliary body effusions. These findings suggest a mydriatic mechanism for our patient’s glaucoma. The weak anticholinergic properties and the noradrenergic effect associated with venlafaxine could precipitate angle closure glaucoma without supraciliary effusions in a patient who is at risk for this condition.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".