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Record W2068388603 · doi:10.1038/ng.523

Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1

2010· review· en· W2068388603 on OpenAlexaff
Sevilla D. Detera‐Wadleigh, Francis J. McMahon, Jens R. Wendland, Nirmala Akula, C. J. M. Steele, René Breuer, Jana Strohmaier, Pierandrea Muglia, Federica Tozzi, John B. Vincent, Sven Cichon, Markus M. Nöthen, Manuel Mattheisen, Wolfgang Maier, Anne Farmer, Florian Holsboer, Martin Preisig

Bibliographic record

VenueNature Genetics · 2010
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsCentre for Addiction and Mental HealthUniversity of Toronto
FundersU.S. National Library of MedicineNational Institute of Mental HealthAlfried Krupp von Bohlen und Halbach-StiftungNational Institutes of HealthSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungUniversität HeidelbergDeutsche ForschungsgemeinschaftGlaxoSmithKlineNational Alliance for Research on Schizophrenia and DepressionChinese Society of Clinical OncologyNational Human Genome Research InstituteWellcome TrustFoundation for the National Institutes of HealthNational Science Foundation
KeywordsGenome-wide association studyMajor depressive disorderMood disordersBipolar disorderOdds ratioSingle-nucleotide polymorphismGenetic associationBiologySNPMeta-analysisMoodLocus (genetics)GeneticsGenotypePsychiatryPsychologyInternal medicineMedicineGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.004
Threshold uncertainty score0.018

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.004
Meta-epidemiology (narrow)0.0020.000
Meta-epidemiology (broad)0.0040.002
Bibliometrics0.0020.003
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0020.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.048
GPT teacher head0.349
Teacher spread0.302 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designMeta-analysis
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations186
Published2010
Admission routes1
Has abstractno

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