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Record W2068573750 · doi:10.1016/j.bbmt.2015.03.024

National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: V. The 2014 Ancillary Therapy and Supportive Care Working Group Report

2015· article· en· W2068573750 on OpenAlexaff
Paul A. Carpenter, Carrie L. Kitko, Mary E.D. Flowers, Juan Gea‐Banacloche, Jörg Halter, Flora Hoodin, Laura Johnston, Ánita Lawitschka, George B. McDonald, Anthony W. Opipari, Bipin N. Savani, Kirk R. Schultz, Sean R. Smith, Karen L. Syrjala, Nathaniel S. Treister, Georgia B. Vogelsang, Kirsten M. Williams, Steven Z. Pavletic, Paul J. Martin, Stephanie J. Lee, Daniel R. Couriel

Bibliographic record

VenueBiology of Blood and Marrow Transplantation · 2015
Typearticle
Languageen
FieldMedicine
TopicHematopoietic Stem Cell Transplantation
Canadian institutionsBC Children's Hospital
FundersNational Institute of Allergy and Infectious DiseasesNational Heart, Lung, and Blood InstituteHealth Resources and Services AdministrationNational Center for Advancing Translational SciencesJosé Carreras Leukämie-StiftungNational Cancer InstituteNational Institutes of HealthAmerican Society for Blood and Marrow TransplantationPediatric Blood and Marrow Transplant ConsortiumCenter for Cancer Research
KeywordsMedicineReferralIntensive care medicineClinical trialChronic diseaseDiseaseHealth careConsensus conferenceGraft-versus-host diseasePhysical therapyFamily medicineInternal medicine

Abstract

fetched live from OpenAlex

The 2006 National Institutes of Health (NIH) Consensus paper presented recommendations by the Ancillary Therapy and Supportive Care Working Group to support clinical research trials in chronic graft-versus-host disease (GVHD). Topics covered in that inaugural effort included the prevention and management of infections and common complications of chronic GVHD, as well as recommendations for patient education and appropriate follow-up. Given the new literature that has emerged during the past 8 years, we made further organ-specific refinements to these guidelines. Minimum frequencies are suggested for monitoring key parameters relevant to chronic GVHD during systemic immunosuppressive therapy and, thereafter, referral to existing late effects consensus guidelines is advised. Using the framework of the prior consensus, the 2014 NIH recommendations are organized by organ or other relevant systems and graded according to the strength and quality of supporting evidence.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.348
metaresearch head score (Gemma)0.465
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.348
Threshold uncertainty score0.803

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.3480.465
Meta-epidemiology (narrow)0.0030.004
Meta-epidemiology (broad)0.0110.019
Bibliometrics0.0140.016
Science and technology studies0.0050.008
Scholarly communication0.0130.006
Open science0.0210.014
Research integrity0.0190.028
Insufficient payload (model declined to judge)0.0070.006

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.259
GPT teacher head0.451
Teacher spread0.192 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations232
Published2015
Admission routes1
Has abstractyes

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