Pneumocystis jirovecii and Cytomegalovirus Co-Infection in AIDS Patients
Bibliographic record
Abstract
A case report of a young woman with insidious dyspnea, cough and weight loss that began 3 months before hospitalization. She referred to occasional cough, wheezing, and fever during the last 2 years. Over one year before, she performed a chest CT that showed diffuse ground-glass opacity (GGO) distributed in both lungs with predominance in the upper and middle areas. She immediately received standardized treatment with sulfamethoxazole-trimethoprim (SMZ-TMP), and ELISA and Western Blot tests for AIDS were performed, and both were positive. Pneumocystis Jirovecci (PCJ) staining and PCR from bronchoalveolar lavage were negative. The GGO seen in CT was inconclusive. After 10 days of treatment, she progressed to being respiratory insufficient. A lung biopsy was done and revealed co-infection of cytomegalovirus (CMV) and PCJ. Although first line therapy for both PCJ and CMV was instituted early, s he had an unfavorable outcome. Despite following the recommendations for diagnosis and treatment of community-acquired pneumonia in immunosuppressed patients , the patient died . The use of molecular biomethods for recognizing sulfur resistance is not usually performed in daily practice and an old question regarding the aggressiveness of co-infection of PCJ and CMV returned in this case. doi: http://dx.doi.org/10.4021/jmc1249w
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.003 | 0.001 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".