MétaCan
Menu
Back to cohort
Record W2068678301 · doi:10.1002/bit.10421

Selective transport and accumulation of alkanes by <i>Rhodococcus erythropolis</i> S+14He

2002· article· en· W2068678301 on OpenAlex
In S. Kim, Julia M. Foght, Murray R. Gray

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueBiotechnology and Bioengineering · 2002
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicMicrobial Metabolic Engineering and Bioproduction
Canadian institutionsUniversity of Alberta
Fundersnot available
KeywordsHexadecaneChemistryPristaneHydrocarbonAlkaneOctadecaneIntracellularOrganic chemistryChromatographyBiophysicsBiochemistryBiology

Abstract

fetched live from OpenAlex

Selective transport and accumulation of n-alkanes by Rhodococcus erythropolis S+14He was studied by growing cells on n-hexadecane, n-octadecane or the branched alkane pristane, and on mixtures of hydrocarbons. Ultrastructural analysis by transmission electron microscopy (TEM) revealed hydrocarbon inclusion bodies present in cells grown on the three alkanes, but not in cells grown on soluble media or exposed to nonmetabolized 2,2,4,4,6,8,8-heptamethylnonane (HMN). n-Hexadecane had the highest rates of accumulation within the cells and higher overall consumption rates relative to the other alkanes. These rates decreased when the molar concentration of n-hexadecane was decreased in hydrocarbon mixtures, but at the same time the accumulation of n-hexadecane in intracellular inclusions became increasingly selective. Sodium azide significantly inhibited the accumulation of n-hexadecane, consistent with an active transport mechanism for accumulation. These results indicate that R. erythropolis S+14He is able to selectively discriminate and preferentially transport n-hexadecane from mixtures of structurally similar alkanes into intracellular inclusions by an energy-driven transport system. This selective membrane transport of hydrocarbon isomers has potential application for separations, bioprocessing, and the development of novel biosensors.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.020
Threshold uncertainty score0.480

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.224
Teacher spread0.212 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it