Bibliographic record
Abstract
Homeobox (Hox) genes encode several subfamilies of nuclear proteins with structurally conserved helix-turn-helix domains that recognize specific DNA sequences [1]. As transcription factors, HOX family members control key events during early development, influencing the organization of body patterning and tissue structures in all species of the animal kingdom from invertebrates to humans [1, 2]. In fully developed organisms, Hox genes contribute to tissue damage and repair mechanisms by controlling apoptosis, receptor signaling, differentiation, motility, and angiogenesis; when expressed abnormally, these activities can have oncogenic consequences [3]. Rhox5 was first identified by Wilkinson et al. [4] as an oncofetal gene (originally called Pem because it was expressed in placenta and embryos) that influenced the progression of T-cell lymphomas to their oncogenic phenotype. During the decade following its discovery, Pem was classified as an orphan member of the Hox gene family that is selectively expressed in reproductive tissues. It therefore followed that Pem was renamed Rhox5 when it was located within a syntenically conserved cluster of other, related reproductive Hox genes on the mouse X chromosome, which was dubbed the Rhox gene family locus in a groundbreaking report in 2005 [5].
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.004 |
| Scholarly communication | 0.003 | 0.002 |
| Open science | 0.001 | 0.003 |
| Research integrity | 0.001 | 0.003 |
| Insufficient payload (model declined to judge) | 0.004 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".