Bibliographic record
Abstract
The aim of this study was to investigate whether brain AT1 receptor stimulation contributes as a hypertensive mechanism to deoxycorticosterone acetate (DOCA)-salt hypertension. Losartan (1mg/4ul) or artificial cerebrospinal fluid (aCSF) was injected into lateral cerebral ventricle in conscious control uninephrectomized Wistar rats or rats with DOCA-salt hypertension for 2 or 4 weeks, and mean arterial pressure (MAP) and heart rates were recorded. In rats with DOCA-salt hypertension resting MAP increased to 144 + 6 mmHg after 2 weeks and to 170 + 5mmHg after 4 weeks versus 115 - 120 mmHg in controls. In 2 week DOCA-salt hypertensive rats MAP started to decline at 4 hours after intracerebroventricular (icv) injection of losartan, and significant decreases in MAP were found at 18 and 24 hours after icv losartan. In 4 weeks DOCA-salt hypertensive rats MAP was significantly decreased at 4, 18 and 24 hours. In both groups MAP decreased to control levels. In control rats, icv losartan had no effect on BP and HR. Icv aCSF did not significantly change MAP and HR in either DOCA-salt hypertensive rats or control rats. In conclusion, normalization of MAP after icv administration of the AT1 receptor antagonist losartan suggests a significant role for brain AT1 receptor stimulation in the induction and maintenance of hypertension in the DOCA-salt hypertensive rat model.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".