Human lipoprotein A - induced reduction of platelet aggregation is not mediated by apolipoprotein a s lysine-binding regions
Bibliographic record
Abstract
Intact lipoprotein (a) (Lp (a)) is known to decrease collagen-stimulated platelet aggregation in vitro, though the nature of the interaction between this lipoprotein and stimulated platelets is unknown. Lysine binding regions of Lp (a) facilitate binding between it and at least one cell type. Epsilon aminocaproic acid (EACA) renders Lp (a)'s lysine binding regions incapable of cellular interaction using those regions. Washed human platelets were presented vehicle alone or with varying concentrations of Lp (a) either not exposed or previously exposed to increasing levels of EACA. In all experiments, EACA failed to affect the impact of Lp(a) on platelet aggregation. It is concluded that the lysine binding regions of Lp (a) do not mediate the intact Lp(a)-induced reduction of collagen-stimulated platelet aggregation in vitro.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".