The calcium receptor modulates the hyperpolarization-activated current in subfornical organ neurons
Bibliographic record
Abstract
Here we report that neurons of the subfornical organ (SFO), a circumventricular structure devoid of a blood-brain barrier, show time-dependent, inward rectification indicative of the presence of a subthreshold, hyperpolarization-activated inward current (Ih). In whole-cell patch clamp experiments of isolated SFO neurons, we observed a Cs+-sensitive Ih in 47% of cells tested. Furthermore, we show that Ih is involved in the generation of evoked bursts in SFO neurons. An allosteric agonist of the extracellular calcium-sensing receptor (CaR) was found to potentiate Ih consistent with our previous observations of CaR-mediated bursting in SFO neurons. These studies indicate that a proportion of SFO neurons express Ih, and this may be one ionic mechanism through which bursting is regulated by various extracellular messengers.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".