Metabolism of 4,7,10,13,16,19-Docosahexaenoic Acid in Isolated Perfused Adult and Newborn Pig Eyes
Bibliographic record
Abstract
We performed open-circuit perfusions of newborn and adult pig eyes to study the age-dependent metabolism of 4,7,10,13,16,19-docosahexaenoic acid (DHA) in this organ. DHA taken up by the perfused eyes was partitioned into glycerolipids, beta-oxidation, and the intracellular nonesterified fatty acid pool. In newborn eyes, DHA was incorporated into structural lipids to a greater extent than in adult eyes. Competition experiments suggest that the adult eye is more selective for DHA than the newborn eye. Finally, pulse-chase data indicate that DHA transport from the circulation across the retinal pigment epithelium and into the retina is more rapid in adult than in newborn eyes. The results are discussed with respect to the rapid accumulation of retinal DHA in early life and the avid retention of this fatty acid by the adult retina.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".