P100IUGR fetuses with abnormal umbilical artery Doppler and elevated S100B protein levels
Bibliographic record
Abstract
Maternal and umbilical blood samples were collected in IUGR pregnancies with abnormal umbilical artery Doppler findings and in controls. S100B protein levels were measured by means of a specific radioimmunoassay and flow velocimetry waveforms were recorded from uterine, umbilical and fetal middle cerebral arteries. We studied the correlation between S100B protein, an acidic calcium binding protein previously demonstrated as a reliable indicator of brain lesion, and the degree of fetoplacental blood flow impairment to examine whether S100B could be helpful in the detection of brain sufference in intrauterine growth retarded (IUGR) fetuses. Mean S100B protein in umbilical plasma were higher (P < 0.05) in IUGR patients (113.5 ± 65.9 fmol/mL) than in controls (52.7 ± 34.8 fmol/mL), and particularly in those cases in which brain sparing was present (169.6 ± 67.8 fmol/mL). Fetal S100B concentrations were correlated with middle cerebral artery PI (r = −0.50, P < 0.05) and with umbilical artery PI/middle cerebral artery PI ratio (r = 0.51, P < 0.05). This study provides evidence that fetal S100B protein is increased in IUGR and suggests that it may play.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".