OP04.05: Is the crux of the heart normal in the conotruncal pathologies? About a series of 40,740 pregnancies
Bibliographic record
Abstract
To examine if a new echographic abnormality of the crux of the heart: the linear insertion of the atrioventricular valves (LIAVV) can be found not only in the pathologies of the inlet but also in those of the outlet (conotruncal pathologies). A prospective study about the sonographic screening of the LIAVV. During 6 to 12 months, 42 physicians of the CFEF (French College for fetal Ultrasonography) practised 40740 examinations of 2nd and 3rd-trimester pregnancies, searching for a LIAVV (with or without defect). A previous training checked that all the physicians were able to visualize the crux of the heart and its offsetting, constant in normal. Out of 39835 interpretable examinations, 63 pathologies of the crux of the heart were found: − 35 LIAVV without defect were presented as an Oral communication, Vancouver, Sept 2005. − 80% (CI 95%: 0.76–0.84)in 35 were associated with a pathology. − 68% (CI 95%: 0.61–0.70)of 35 were trisomies 21. We present here new data about the − 28 LIAVV with defect also found in this study: − 7 had abnormal kayotypes: 5 trisomies 21, 1 trisomy 18. In all these 6 cases the defect belonged to the inlet. In the 7th case, a del 22q11, the defect was an outlet defect-21 had a normal karyotype: 2 Viscero atrial heterotaxias with a complete AVSD. 3 other showed an inlet defect (partial or complete AVSD). But the remaining 16 cases were Cono truncal pathologies: the defect was actually not in the inlet but in the outlet. 17 cases (1del 22 q11, 16 normal karyotype) out of 28 LIAVV with defect, 61% (CI 95%:0.55–0.66) were conotruncal pathologies. All these LIAVV, found on the 4 Chamber view, were associated with an outlet defect. That means that CT pathologies actually known as being prenatally diagnosed by exploring the outlet could be highly suspected on the fetal 4 chamber view when the crux of the heart is well examined.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.007 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".