Aggressive Variant of Primary Cutaneous Anaplastic Large T-Cell Lymphoma
Bibliographic record
Abstract
Primary cutaneous anaplastic large cell lymphoma (ALCL) represents less than 2% of all T-cell lymphomas and usually manifests as a solitary cutaneous lesion generally in older males. It is an indolent disorder with a survival rate of 90% at 10 years, and rarely shows extracutaneous dissemination. The FDG avidity of the lesions of cutaneous ALCL is the lowest reported among T-cell lymphoma subtypes. However, the available positron emission tomography (PET) literature has not taken account of a subtype of primary cutaneous ALCL that presents with extensive limb disease, has a much more aggressive course, and responds poorly to conventional therapy. We report serial F-18 FDG PET/CT imaging of a 72-year-old man with this aggressive subtype of primary cutaneous ALCL. This case demonstrates that despite the low reported sensitivity of FDG PET/CT in cutaneous ALCL, PET/CT may in fact play a vital role in identifying patients with the more aggressive extensive limb disease subtype, and help guide therapeutic decisions toward much better outcomes than currently achieved.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.008 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".