Poly(ethylene glycol)-<i>b</i>-poly(ε-caprolactone) Micelles Containing Chemically Conjugated and Physically Entrapped Docetaxel: Synthesis, Characterization, and the Influence of the Drug on Micelle Morphology
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Docetaxel (DTX), a chemotherapeutic agent, was coupled to the hydrophobic block of poly(ethylene glycol)-b-poly(epsilon-caprolactone) (PEG-b-PCL) copolymers synthesized by metal free ring-opening polymerization. Synthesis of the copolymers and the copolymer-drug conjugate (PEG-b-PCL-DTX) were confirmed by (1)H NMR and GPC analyses. The PEG-b-PCL-DTX conjugates had a approximately 1:3 drug/copolymer ratio (w/w) and a low critical micelle concentration in aqueous solution (14 mg/L). Encapsulation of DTX in PEG-b-PCL-DTX micelles resulted in an 1840-fold increase in the aqueous solubility of the drug. Release of physically encapsulated DTX from PEG-b-PCL-DTX micelles was slower than drug release from PEG-b-PCL micelles due to the improved compatibility between DTX and the micelle core. Core-conjugated DTX was released over the course of one week indicating that PEG-b-PCL-DTX micelles have the capacity for sustained drug release in the absence of physically encapsulated drug. Importantly, conjugation of DTX to the core-forming block had a profound effect on the morphology of the copolymer aggregates.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it