Desensitization and internalization mechanisms of the 5‐HT4 receptors
Bibliographic record
Abstract
Abstract The serotonin 5‐HT4 receptor is a member of the superfamily of G‐protein‐coupled receptors (GPCRs) that mediates many physiological effects in the central nervous system and its periphery. Recently, a 5‐HT4 receptor agonist was shown to produce faster antidepressant‐like response in animal models in comparison to conventional antidepressants, and this effect persists for at least 2 weeks of treatment without generating tolerance. Importantly, long‐term administration of various classes of antidepressants has been reported to induce desensitization and/or downregulation of 5‐HT4 receptors in brain areas implicated in the physiopathology of depression. These observations point to the importance of studying the mechanisms of desensitization and regulation of the 5‐HT4 receptors since they seem distinctively implicated in therapeutic response to the classical selective serotonin reuptake inhibitors (SSRIs) and novel faster acting antidepressants. Hence, desensitization and internalization mechanisms of the 5‐HT4 receptors have been characterized with special emphasis on the 5‐HT4a and 5‐HT4b isoforms.WIREs Membr Transp Signal2012, 1:779–788. doi: 10.1002/wmts.52 For further resources related to this article, please visit the WIREs website .
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".