Intramyocardial injection of mesenchymal stromal cells in patients with severe stable coronary artery disease and refractory angina - final 3 year follow-up
Bibliographic record
Abstract
Rapid Fire -Treating ischaemia and infarction: where next?/ State of the Art -Arrhythmias: the future of cardiac arrhythmias 667 is abolished by bilateral vagotomy or silencing of vagal preganglionic neurones in the brainstem.In this study we determined whether cardiac innervation provided by the right and the left vagus are equally important in mediating cardioprotection established by RIPrec and RIPerc.Methods: Rat model of myocardial ischaemia/reperfusion injury involved 30 min of left coronary artery occlusion followed by 120 min of reperfusion.RIPrec (n=10) and RIPerc (n=10) were induced by 15 min occlusion of both femoral arteries applied 25 min prior to and 10 min after the onset of MI, respectively.Sham-RIc procedure involved dissection of both femoral arteries without occlusion (n=8).Bilateral or unilateral right/left vagotomies were performed 40 min before the onset of MI (n=6-10).Results: There were no significant differences in haemodynamic parameters between the groups of animals during the experiments.RIPrec and RIPerc conferred potent cardioprotection as evident from significant reductions in infarct size (19±5% and 21±7%, respectively vs 46±7% in sham-RIc group; p<0.001).Bilateral vagotomy abolished cardioprotection established by either RIPrec or RIPerc.Unilateral right or left vagotomy abolished cardioprotection induced by RIPerc (38±7% and 38±9%, respectively; p<0.001) but had no effect on cardioprotection established by RIPrec (30±7% and 31±13%, respectively; p=NS).Conclusions: These data indicate that the activity of either right or left vagus nerve is sufficient to mediate cardioprotection established by remote ischaemic preconditioning.Functional integrity of both nerves is required to establish cardioprotection when remote conditioning stimulus is applied during myocardial ischaemia.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".