Clopidogrel Is Safe Early after On- and Off-pump Coronary Artery Bypass Surgery
Why this work is in the frame
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Bibliographic record
Abstract
OBJECTIVES: The goal of this study was to assess the safety of early postoperative clopidogrel in patients undergoing on-pump and off-pump coronary artery bypass graft (CABG) surgery. METHODS: Observational data was collected prospectively on 117 consecutive patients who underwent primary multivessel CABG between July 2002 and June 2005. When postoperative chest tube drainage was < or =50 cc/h for 2 hours, daily clopidogrel (75 mg) and aspirin (81 mg) were initiated in 63 patients (Group CA) versus aspirin alone in 54 patients (Group A). Demographic, operative, and postoperative data were compared with linear regression and propensity-score based techniques. RESULTS: Total chest tube drainage and drainage after patients received antiplatelet agents were equivalent between groups. Clopidogrel administration did not increase the incidence of reexploration, transfusion, or the quantity of blood products transfused. No mortality or extrathoracic bleeding occurred in either group, and there were no differences in the incidence of adverse myocardial events or hospital length of stay. CONCLUSIONS: When given according to a predefined postoperative protocol, early postoperative clopidogrel can safely be administered in on-pump and off-pump CABG patients, without increasing the risk of bleeding complications. Evaluation of the benefits of clopidogrel therapy early after CABG in a randomized setting is ongoing.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.002 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it