Pituitary Infundibulum Hemangioblastoma Detected by Dynamic Enhancement MRI
Bibliographic record
Abstract
Hemangioblastomas in the pituitary stalk are extremely rare; only 13 cases have been described in the past.[1][2][3][4][5][6] Detected by a dynamic contrast-enhanced magnetic resonance imaging (MRI), a case of pituitary infundibulum hemangioblastomas (HBL) was reported by us with tumor volume only 0.016 cm 3 . CASE REPORTA 28-year-old woman was admitted to our hospital with a 27month history of galactorrhea and alopecia.No obvious tumor on the pituitary infundibulum was found by a cranial MRI (Figure 1), however, it indicated multiple masses in the vermis cerebellum, medulla oblongata, and dorsal portion of thoracic spinal cord 1-2 and syringomyelia from cervical to thoracic spinal cord.Previous medical history showed she was healthy and she was on no medications.Her menstruation was regular without a history of oligomenorrhea and no diabetes insipidus was found.On admission, the neurological examination revealed her slight dissociated sensory loss and slight weakness on the left hand.Her left extremities' strength was V -.The opthalmological examination was normal and abdominal computer tomography scans indicated a pancreatic cyst.Von Hippel-Lindau (VHL) disease was diagnosed based on the clinical criteria.Serum hormone levels including total thyroxine 3, total thyroxine 4, thyroid stimulating hormone, free thyroxine 3, free thyroxine 4, estradiol, progesterone, human growth hormone, and testosterone were in the normal ranges.The concentration of prolactin in the serum was slightly elevated (28.35ng/ml, normal range 1.39-24.20ng/ml),luteinizing hormone (0.38mIU/ml, normal range 0.40-20.00IU/ml),follicle-stimulating hormone (1.43mIU/ml, normal range 2.00-13.00IU/ml),cortisol (23.66ng/ml, normal range 50.00-250.00ng/ml)were slightly decreased.A suboccipital craniotomy and a C1, T1-T3 laminectomy were performed, Macroscopically, lesions in the vermis cerebellum, medulla oblongata and thoracic spinal cord 1-2 were explored and removed completely.Hemangioblastomas were confirmed through pathologic study.Symptoms of galactorrhea and alopecia of the patient still existed postoperatively.Magnetic resonance imaging (including dynamic contrast enhancement MRI with thin coronal scans through the sella) was performed at one week and three months after the surgery.On the second dynamic contrast-enhanced MRI, (Figure 2 a-d) a tiny enhanced mass with volume 4x2x2 mm 3 was detected on the pituitary infundibulum.Based on the clinical data and criteria, 6 it was diagnosed as pituitary infundibulum hemangioblastoma.Three months after the surgery serum hormone levels including total thyroxine 3, total thyroxine 4, thyroid stimulating hormone, free thyroxine 3, free thyroxine
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.002 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".