Effects of micronized fenofibrate versus atorvastatin in the treatment of dyslipidaemic patients with low plasma HDL‐cholesterol levels: a 12‐week randomized trial
Bibliographic record
Abstract
Abstract. Després J‐P, Lemieux I, Salomon H, Delaval D (CHUL Research Center, Ste‐Foy, Québec, Laval Hospital Research Center, Ste‐Foy, Québec, Canada and Laboratoires Fournier, Garches, France). Effects of micronized fenofibrate versus atorvastatin in the treatment of dyslipidaemic patients with low plasma HDL‐cholesterol levels: a 12‐week randomized trial. J Intern Med 2002; 251: 490–499. Background. Studies have suggested that raising low levels of high‐density lipoprotein cholesterol (HDL‐C) may be an important target for the prevention of coronary heart disease. Objective. To compare the ability of micronized fenofibrate and atorvastatin to increase plasma HDL‐C levels. Design. Multicentre, randomized open‐label study. Settings. The study was conducted in 19 centres across the UK and Canada. Subjects. One hundred and eighty‐one patients were randomized and the full analysis set included 165 nondiabetic patients with low HDL‐C (women <46 mg dL −1 , i.e. 1.2 mmol L −1 and men <43 mg dL −1 , i.e. 1.1 mmol L −1 ): 86 patients in the atorvastatin group and 79 patients in the micronized fenofibrate group. Interventions. Micronized fenofibrate (200 mg day −1 , 87 patients) or atorvastatin (10 mg day −1 , 94 patients) for a period of 12 weeks. Main outcome measures. Percent change in HDL‐C levels. Results. After 12 weeks of treatment, the mean percent change from baseline in HDL‐C was significantly higher in the micronized fenofibrate group (13.3%) compared with the atorvastatin group (5.3%, P =0.0003). The magnitude of such relative change was inversely related to the baseline HDL‐C levels only in the micronized fenofibrate group. Furthermore, in the fenofibrate treatment group, 50.9% of the patients (29 of 57 patients) with a baseline HDL‐C <40 mg dL −1 achieved a plasma HDL‐C level above 40 mg dL −1 after 12 weeks of treatment versus 27.9% of the patients (19 of 68 patients) in the atorvastatin group ( P =0.01). Conclusions. On the basis of (1) the greater impact of fenofibrate than atorvastatin on HDL‐C levels and (2) the greater proportion of dyslipidemic patients achieving HDL‐C levels above 40 mg dL −1 with fenofibrate than atorvastatin, it is suggested that micronized fenofibrate should be considered as a good therapeutic option to treat dyslipidemic patients with low HDL‐C and moderately elevated LDL‐C concentrations.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".