Possible Influence of Dopaminergic Receptor in Maintenance of Thyroid Hormone Homeostasis: A Study in Adult Rat Brain
Bibliographic record
Abstract
Background: The role of thyroid hormone (TH) disbalance in genesis of psychological disturbances in the adult humans is well known. A phenomenon of ‘central thyroid hormone homeostasis’ characteri zed by increased synaptosomal T3 content, deiodinase type II (DII) activity and cAMP level, is known to exist during peripheral hypothyroidism. This phenomenon tries to counteract the adverse psychobehavioural manifestations commonly associated with TH deficiency. A close physiological association between sympathetic nervous system activity and TH is well known. Dopamine, a predominant catecholamine neurotransmitter in the mammalian brain, controls a variety of functions including locomotion, cognition, emotion and also affects neuroendocrine secretion. In the present study relationship between TH and dopamine has been presumed to be involved in the maintenance of ‘central thyroid hormone homeostasis’ in adult rat. M ethods: We injected specific dopaminergic receptor agonists and antagonists along with an antithyroid drug (PTU) to find out any effect on ‘central homeostasis’ in adult rat. Results: The dopaminergic agonist did not alter the onset of ‘central homeostasis’, but prolonged its duration by maintaining the control level of cerebral T3. Injection of the antagonist did not cause any perturbation. These results have been supported by parallel changes in cerebrocortical DII activity and cAMP. Conclusion: In the present experiment a striking feature is that a D 2 -receptor mediated inhibition of cAMP accumulation has been reversed to D 1 -receptor mediated stimulation of cAMP accumulation probably by the effect of ‘central thyroid hormone homeostasis’. This effect of D 2 -agonist can be therapeutically utili zed for prolonging the duration of homeostasis. doi:10.4021/jem101w
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".