Activation of Ovarian Procathepsin B by Coexistent Cathepsin D during Late Oocyte Maturation in Scad.
Bibliographic record
Abstract
In pelagic egg-spawning marine fish, hepatically derived vitellogenin undergoes limited proteolysis within the follicles during early oocyte maturation followed by additional degradation during late oocyte maturation. This study demonstrates the role of cathepsin D expressed in late maturating oocytes of round scad Decapterus maruadsi, in relation to ovarian cathepsins B and L that are possible agents causing yolk degradation. Ovarian cathepsins B, D and L in late oocyte lysate were isolated by gel filtration, and their respective molecular masses were estimated as 26.7, 34.9 and 29.9 kDa. The effect of pepstatin, a potent inhibitor of cathepsin D, was examined on their activities in the oocyte lysate and isolates of cathepsins. In both sources, the activity of cathepsin D was completely inhibited whereas that of cathepsin L was not inhibited. However, the activity of cathepsin B in the lysate was significantly reduced while no inhibition of its activity was observed in the isolate. Results indicate that ovarian cathepsin D is involved in activation of coexistent procathepsin B during late oocyte maturation in scad.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".