Early-Adult Life Correlates of Personality in Parkinson’s Disease
Bibliographic record
Abstract
Background : Parkinson’s disease (PD) patients have been described as having an introverted, rigid and harm-avoidant personality, which present decades before motor symptoms begin. Previous studies have relied on subjective reports about patients’ premorbid personalities. The objectives of this study were to examine current personality profiles of PD patients and to assess how personality indicators of early-adult life correlate with current personality. Methods: Data were collected from 89 PD cases and 99 controls through in-person assessments of current personality characteristics and early-adult life personality indicators based on activities and lifestyle patterns during ages 20 - 35 years. Associations of latent variables representing early-adult activity risks, lifestyle risks and routinization with current personality characteristics were studied using Pearson correlations, partialling out the effects of age, sex and education. Results: Greater current levels of neuroticism (OR = 1.05 (95% CI 1.00 - 1.11)) and harm-avoidance (OR = 1.07 (95% CI 1.00 - 1.15)) were evident in cases compared to controls, adjusting for age, sex and education. Significant correlations between early-life indicators and late-life personality characteristics were consistent among cases and controls for associations of early-adult life routinization with current measures of neuroticism (cases: r = 0.33, P = 0.01; controls: r = 0.26, P = 0.04), extraversion (cases: r = -0.33, P = 0.01; controls: r = -0.33, P = 0.04), novelty-seeking (cases: r = -0.33, P = 0.015; controls: r = -0.34, P = 0.007) and harm-avoidance (cases: r = 0.47, P = 0.0003; controls: r = 0.45, P = 0.0002) and for early-adult life activity risks with harm-avoidance (cases: r = -0.47, P = 0.0004; controls: r = -0.42, P = 0.0006). Conclusion: Current personality profile of PD cases, reflected by higher neuroticism and harm-avoidance, may reflect stable personality traits characterized by greater routinization and lower risk-taking in earlier adult life. J Neurol Res. 2014;4(2-3):51-62 doi: http://dx.doi.org/10.14740/jnr280w
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".