Synthesis, X‐ray Characterisation and Studies of the New Ionic Complex [Bis(pyridin‐2‐yl) disulfide] Triiodide, Obtained by Oxidation of 2‐Mercaptopyridine with I<sub>2</sub> − Implications in the Mechanism of Action of Antithyroid Drugs
Bibliographic record
Abstract
Abstract The reaction of 2‐mercaptopyridine (C 5 H 5 NS or PYSH) with diiodine in a molar ratio of 1:2 in dichloromethane led to the oxidation and dimerization of the ligand and formation of [(PYS−PYSH) + ·I 3 − ]. The compound was characterised by elemental analysis, DTA‐TG, FT‐Raman, FT‐IR, UV/Vis and 1 H NMR spectroscopy. The crystal structure of the complex has been determined by X‐ray diffraction at 293(2) K. The compound [(C 5 H 4 NS−SNC 5 H 5 )I 3 ] is monoclinic with the space group P 2 1 and a = 8.230(2) Å, b = 35.708(7) Å, c = 11.369(2) Å, β = 91.86(3)° and Z = 8. The results are discussed in relation to the mechanism of action of antithyroid drugs. The easy oxidation of PYSH by I 2 to form the monocationic disulfide complex [(PYS−PYSH) + ·I 3 − ] is similar to the case of the antithyroid drug methimazole (MMI) and may indicate that PYSH might also possess antithyroid properties similar to those of MMI. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".