Effects of Middle Ear Application of Cipro HC Otic Suspension in an Animal Model
Bibliographic record
Abstract
The objective of this study was to examine whether ciprofloxacin-containing otic drops (Cipro HC Otic Suspension; 0.2% ciprofloxacin, 0.1% hydrocortisone; Alcon, Ontario, Canada) are cochleotoxic in the chinchilla animal model. Five chinchillas in total underwent these studies. Pretreatment distortion-product otoacoustic emissions (DPOAEs) were measured in each ear, followed by a random injection of Cipro to one ear and normal saline to the other. Injections consisted of 0.2 mL into the middle ear cavity (bulla) for 5 consecutive days. Post-treatment DPOAEs and auditory brainstem responses were measured at 1 month, and cochlear hair cell integrity was assessed by scanning electron microscopy (SEM). All animals had normal pretreatment DPOAEs. One month after Cipro instillation, DPOAE levels decreased in three of the animals. No significant change was seen in the ears treated with saline. On SEM examination, the integrity of the stereocilia of the inner and outer hair cells demonstrated no histologic evidence of significant cochlear damage. The finding of reduced DPOAEs suggests a mild local middle ear inflammation caused by the ciprofloxacin or some other component or property of Cipro.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".