Nanoscale Membrane Organization and Receptor Signaling in T- Lymphocytes
Bibliographic record
Abstract
The presence of microdomains (i.e., lipid rafts) in the plasma membrane and their proposed role(s) in the signal transduction by cell surface receptors, particularly in immune cells, has elicited broad interest yet much debate. Here, we aim to review some observations made by our and other groups over past years on the structural and functional properties of membrane microdomains, focusing mainly on T cells and more particularly on activation of signaling cascades triggered by T-cell receptor (TCR) and Fas/CD95, respectively. We will focus on the progress made at both the experimental and conceptual levels. We will then discuss our recent studies on the identification and characterization of nano-sized membrane domains in the plasma membrane of living cells using an original fluorescent correlation spectroscopy (FCS) approach. Keywords: Lipid rafts, membrane microdomains, T-cell receptor, Fas, CD95, signal transduction, live cells, fluorescent correlation spectroscopy
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".