Fluconazole use during the first trimester of pregnancy was not associated with most major birth defects
Bibliographic record
Abstract
ACP Journal Club21 January 2014Fluconazole use during the first trimester of pregnancy was not associated with most major birth defectsLaura A. Magee, MD, FRCPC, MSc, FACPLaura A. Magee, MD, FRCPC, MSc, FACPUniversity of British Columbia, Vancouver, British Columbia, Canada (L.A.M.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-160-2-201401210-02012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationMølgaard-Nielsen D, Pasternak B, Hviid A. Use of oral fluconazole during pregnancy and the risk of birth defects. N Engl J Med. 2013;369:830-9. https://pubmed.ncbi.nlm.nih.gov/23984730Clinical Impact RatingsGIM/FP/GP: Infectious Disease: References1 Lopez-Rangel E, Van Allen MI. Prenatal exposure to fluconazole: an identifiable dysmorphic phenotype. Birth Defects Res A Clin Mol Teratol. 2005;73:919-23. [PMID: 16265639] Google Scholar2 Tiboni GM, Marotta F, Del Corso A, Giampietro F. Defining critical periods for itraconazole-induced cleft palate, limb defects and axial skeletal malformations in the mouse. Toxicol Lett. 2006;167:8-18. [PMID: 16987620] Google Scholar3 Marotta F, Tiboni GM. Molecular aspects of azoles-induced teratogenesis. Expert Opin Drug Metab Toxicol. 2010;6:461-82. [PMID: 20102286] Google Scholar Author, Article, and Disclosure InformationAffiliations: University of British Columbia, Vancouver, British Columbia, Canada (L.A.M.)This article was published at Annals.org on 7 January 2014. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 January 2014Volume 160, Issue 2Page: JC12KeywordsAntifungalsCohort studiesCongenital disordersDrugsHeartInfantsPregnancyResearch fundingSafetyVentricular septal defects ePublished: 21 January 2014 Issue Published: 21 January 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.012 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.017 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".