MétaCan
Menu
Back to cohort

Pre-analytic and analytic sources of variations in thiopurine methyltransferase activity measurement in patients prescribed thiopurine-based drugs: A systematic review

2011· review· en· W2080650514 on OpenAlexaff
Evelin Loit, Andrea C. Tricco, Sophia Tsouros, Margaret Sears, Mohammed Ansari, Ronald A. Booth

Bibliographic record

VenueClinical Biochemistry · 2011
Typereview
Languageen
FieldMedicine
TopicAcute Lymphoblastic Leukemia research
Canadian institutionsChildren's Hospital of Eastern OntarioOttawa HospitalSt. Michael's HospitalUniversity of Ottawa
FundersNational Center for Complementary and Alternative MedicineU.S. Public Health ServiceAgency for Healthcare Research and QualityU.S. Department of Health and Human Services
KeywordsThiopurine methyltransferasePharmacologyMedicineEfficacyMethyltransferaseDrugAzathioprineEnzyme assayInternal medicineEnzymeChemistryBiochemistry

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.010
metaresearch head score (Gemma)0.045
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (broad)
Consensus categoriesnone
DomainCandidate signal: Methods · Consensus signal: none
Study designCandidate signal: Systematic review · Consensus signal: Systematic review
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.991
Threshold uncertainty score0.051

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0100.045
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0090.009
Bibliometrics0.0040.006
Science and technology studies0.0000.001
Scholarly communication0.0020.001
Open science0.0020.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.079
GPT teacher head0.386
Teacher spread0.307 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designSystematic review
DomainMethods
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations14
Published2011
Admission routes1
Has abstractno

Explore more

Same venueClinical BiochemistrySame topicAcute Lymphoblastic Leukemia researchFrench-language works237,207