Bone complications of androgen deprivation therapy: screening, prevention, and treatment
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
PURPOSE OF REVIEW: Contemporary treatments for prostate cancer have probably contributed to prolonged survival in a significant number of patients. Those under androgen deprivation therapy (ADT) face, however, the danger of increased bone complications that may arise due to compromised bone integrity. Such complications include fractures due to accelerated bone resorption and pathologic fractures due to the metastases that often occur with cancer progression. We herein discuss available strategies to avoid bone loss in this patient population. RECENT FINDINGS: Present recommendations to counter the effects of ADT on bone integrity include calcium and vitamin D supplementation. Bisphosphonates are helpful in reducing bone resorption and improving bone mineral density. New agents such as denosumab (a monoclonal antibody against RANK ligand) and selective estrogen receptor modulators seem to hold promise with respect to fracture risk reduction in patients on ADT. SUMMARY: Bone health in patients suffering from prostate cancer is gaining increased attention, especially with active agents reaching maturity in randomized trials. Ultimately, bone preservation should become the concern of every physician caring for patients on ADT.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it