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The Power of Observation

2011· letter· en· W2082202469 on OpenAlexaff
David A. Clark

Bibliographic record

VenueAmerican Journal of Reproductive Immunology · 2011
Typeletter
Languageen
FieldMedicine
TopicOvarian function and disorders
Canadian institutionsMcMaster University
Fundersnot available
KeywordsEmbryo transferCausationEmbryoIn vitro fertilisationAndrologyLive birthMedicinePhysiologyGynecologyPregnancyBiologyGenetics

Abstract

fetched live from OpenAlex

PROBLEM: In the golden age of evidence-based medicine, how should one view the cohort-controlled study of IVIG + anti-TNF-α (Humira) in recurrent in vitro fertilization (IVF) failure patients with an elevated Th1/Th2 cytokine production ratio. METHOD: Critical analysis of the nature of evidence for causation. RESULTS: A better delivery rate and a live birth rate per embryo approaching the estimated maximum possible in patients whose elevated Th1/Th2 ratio corrected to normal compared to those with an incomplete correction is a strong argument for causation. A maximal improvement when treatment was given 61-120 days before embryo transfer suggests a possible mechanism via improving the physiology during follicle development. CONCLUSION: Independent replication to verify results would augment power.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.199
Threshold uncertainty score0.713

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.002
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.019
GPT teacher head0.251
Teacher spread0.232 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations19
Published2011
Admission routes1
Has abstractyes

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