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Record W2083223029 · doi:10.1139/g03-116

Comment on "Epigenetics and the renaissance of heresy"

2003· article· en· W2083223029 on OpenAlexvenueno aff
Rama S. Singh

Bibliographic record

VenueGenome · 2003
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicEvolution and Genetic Dynamics
Canadian institutionsnot available
Fundersnot available
KeywordsInheritance (genetic algorithm)MacroevolutionBiologyMendelian inheritanceModern evolutionary synthesisDarwinismGeneticsEpigeneticsEvolutionary biologyGenePhylogenetics

Abstract

fetched live from OpenAlex

Lamarckian inheritance (i.e., inheritance of acquired character) and Richard Golschmidt's concept of "systemic mutations" and their role in macroevolution have been two of the most controversial topics in the history of evolutionary biology. The concept of Lamarckian inheritance was put to rest first by Weismann's germplasm theory and experiment and later by the discovery of Mendelian inheritance. Goldschmidt's theory of macroevolution by systemic mutations was put to rest by the discovery of DNA's structure and subsequent demonstration showing allelic variation as the basis for genetic and phenotypic differences observed among organisms. Some authors are using recent demonstrations of epigenetic inheritance in higher organisms to support Lamarckian inheritance and Golschmidt's theory of macroevolution by systemic mutations. In this paper, I show that the recent discoveries related to mutations, such as the so called "directed" mutations in bacteria, and epigenetic inheritance in higher organisms are basically an extension of the notion of "mutation" and thus of the concept of "heritable variation" required for evolution. While the new discoveries of the laws of developmental transformations are enriching our knowledge of the intricate relationship between genotype and phenotype, the findings of epigenetic inheritance do not challenge the basic tenets of the neo-Darwinian theory of evolution, as other than producing new variation no new processes of evolutionary change have been added to the ones we already know — mutation, migration, selection, and drift.Key words: neo-Darwinian theory of evolution, epigenetics, Lamarckian inheritance, systemic mutations, speciation, macroevolution.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.005
metaresearch head score (Gemma)0.018
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.030
Threshold uncertainty score0.031

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0050.018
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0040.010
Scholarly communication0.0040.006
Open science0.0060.003
Research integrity0.0300.037
Insufficient payload (model declined to judge)0.0090.006

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.226
Teacher spread0.218 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2003
Admission routes1
Has abstractyes

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