Phosphatidylcholine‐specific phospholipase C activity and level increase evidently in thromboangitis obliterans
Why this work is in the frame
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Bibliographic record
Abstract
Thromboangitis obliterans (TAO) is considered to be an inflammatory disease. Previous research has demonstrated that phosphatidylcholine-specific phospholipase C (PC-PLC) plays critical roles in various inflammatory responses. However, the connection between PC-PLC and TAO is undetermined. Therefore, we sought to investigate whether PC-PLC was implicated in TAO. In our study, there were two groups: TAO group and control group. The PC-PLC activity of serum of two groups (16 TAO patients and 11 controls) was detected by PC-PLC activity assay. The level and distribution of PC-PLC in posterior tibial arteries in seven TAO patients and four controls were detected by immunofluorescence staining method. PC-PLC activity increased greatly in serum of TAO patients. Immunofluorescence analysis also revealed an upregulation of PC-PLC in the vascular endothelium of TAO patients. Our data suggest that PC-PLC activity and level increase obviously in TAO patients. Our study may provide new clues for seeking pathogenesis of TAO. Furthermore, it may bring new insights into clinical diagnosis and treatment of TAO.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it