Seminal fluid anaphylaxis
Bibliographic record
Abstract
Seminal Fluid Anaphylaxis (SFA) is a rare condition caused by IgE mediated sensitization to seminal proteins during or after coitus. It has been reported about 80 times in the medical literature ranges in symptomatology from local pruritus to serious systemic reactions. This is the first known documented case in Canada. One case is presented including clinical course and positive skin prick testing to husband’s seminal fluid after consultation with an allergist and obtaining written consent. A 54 year-old woman with no atopic history was referred for evaluation after four progressive episodes of post-coital reactions with her husband. The first two episodes consisted of itching of both palms and soles of feet with minimal vaginal pruritus. After abstaining, a third episode a month later consisted of hives on the patient’s legs and back with significant vaginal pruritus. The fourth episode the patient developed vaginal and generalized pruritus, urticaria, palpitations and trouble breathing through her nose, immediately post-coital. All symptoms resolved spontaneously with no treatment. Skin prick testing was conducted using the partner’s seminal fluid to confirm the clinical suspicion of SFA, producing a wheal of 8mm and flare of 5cm. The partner’s seminal fluid will be fractionated to determine the specific amino acid sequence of interest by serum-specific IgG/IgE by ELISA to the seminal plasma and plasma proteins. An SDS-PAGE and IgE immunoblot assay will confirm specific activity to the semen. Of clinical relevance, mass production of this protein will be used for local or systemic immunotherapy to prevent future SFA.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.010 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".