ENTRAINMENT ELICITS PERIOD AFTEREFFECTS IN<i>NEUROSPORA CRASSA</i>
Bibliographic record
Abstract
Circadian clocks continue to oscillate in constant conditions with their own period (tau) and entrain to a cyclic environment by adjusting their intrinsic period to that of the zeitgeber. When circadian clocks are released from entrained to constant conditions, the tau of their initial free-run often depends on the nature of the prior zeitgeber. These postentrainment effects on period (tau-aftereffects) have predominantly been reported for animals but, so far, not fungi. The authors therefore investigated tau aftereffects in the classic circadian model system Neurospora crassa. The standard laboratory strain frq+, the short-period mutant frq(1), and the long-period mutant frq(7) were entrained to 11 different photoperiods in a 24-h day (2-22 h) and to zeitgebers with six different T (16-26 h), and then released to constant darkness. tau-Aftereffects in response to different photoperiods correlated weakly with prior photoperiod in frq+ and were unsystematic in both period mutant strains. Strength and direction of the tau-aftereffect in zeitgeber cycles with different T depended on their length and on the strain, showing a negative correlation with zeitgeber length in frq+ and positive correlations in frq(1) and frq(7). It has been proposed that tau-aftereffects are based on interactions of oscillators within a cellular network. The present findings in Neurospora, which grows as a syncytium, suggest that tau-aftereffects also exist in circadian systems based on multioscillatory networks organized at the molecular level.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".