Sphingosine-1 phosphate promotes thymic atrophy during sepsis progression
Bibliographic record
Abstract
T-cell depletion is a marker of the hypo-inflammatory phase of sepsis [ 1 , 2 ]. Systemic T-cell loss could be caused i.a. by thymus involution during sepsis, thus contributing to immune paralysis [ 3 ]. Usually, thymic T-cell egress is mediated by a sphingosine-1-phosphate (S1P) gradient. That is, T cells leave the thymus towards an increased S1P-level in the periphery (blood/lymph) [ 4 ]. A disruption of this S1P gradient blocks T-cell emigration. S1P is produced by sphingosine kinases 1 and 2 (SPHK1 and SPHK2), which are ubiquitously expressed [ 5 ]. Apoptotic cells are known to release S1P [ 6 ]. We suggest that apoptotic events in the thymus during sepsis increase S1P levels, thereby disrupting the gradient and preventing egress of T cells from the thymus.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".