PEDIATRIC INFLAMMATORY BOWEL DISEASE: THE BRITISH COLUMBIA EXPERIENCE
Bibliographic record
Abstract
Background: Limited data is available regarding incidence and prevalence of inflammatory bowel disease (IBD) in the Canadian Pediatric population. Epdemiologic studies suggest an increase in prevalence of IBD. British Columbia Childrens Hospital (BCCH) is uniquely positioned as the only pediatric tertiary care hospital in the province with all provincial pediatric gastroenterologists practicing at this site. Aim: To investigate epidemiology and clinical characteristic of IBD in children referred to BCCH between 1985 and 2005. Methods: A review was undertaken with at diagnosis data collected from medical charts of all patients ≤16 years diagnosed with IBD at BCCH between the study period. Age, gender, ethnicity, family history of IBD, type and extent of disease were included. Provincial population statistics were obtained from Statistics Canada. Diagnosis and classification of disease was based on standard clinical, endoscopic, radiological and histological criteria. Results: A total of 570 children were diagnosed with IBD; 391(68.6%) with Crohn disease (CD), 114 (20%) with Ulcerative Colitis (UC) and 56 (9.8 %) with Indeterminate Colitis (IC). The incidence rate for IBD between years 2001-2005 was 7.21/105 (5.06/105 for CD, 1.14/105 for UC and 1.01/105 for IC). The median age at diagnosis was 12 ± 3.63 (SD) years (range 0.8-16 years) and the male to female ratio was 1.20:1. Seventy nine percent of the population was Caucasian (4.2% Ashkenazi Jews), 12.9% East Indian, 2.8% Asian and 5% additional visible minorities. A family history of IBD was evident in 36.3% of children (36% 1st degree, 64% 2nd degree). Twenty two percent of the CD cohort had isolated colonic disease. Conclusion: The incidence rate and extent of disease of the pediatric IBD cohort of British Columbia are similar to published pediatric IBD data, while the high incidence of family history is not well reported. Moreover, the study found a disproportionate distribution of IBD in the ethnically diverse population of British Columbia.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.005 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".