Effect of Community-Based Group Prenatal Physical Activity on Pre-eclampsia Rate
Bibliographic record
Abstract
Disorders of pregnancy that are associated with inflammation are major contributors to poor pregnancy outcomes, prematurity and birth defects. Pre-eclampsia (PE) is one such disorder characterized by maternal inflammation and resulting in dysfunctions in immune, cardiovascular and metabolic systems. It is cured only by birth of the baby - usually preterm - and composes 15% of preterm births in the U.S.; rates are higher in the developing world. In non-pregnant people, inflammation is treated with and prevented by pharmaceuticals and lifestyle methods like physical activity (PA). Most medications are contraindicated in pregnancy, but PA during pregnancy has been found safe, healthy and beneficial for mom and baby. Evidence shows that PA can enhance pregnancy outcome, and decrease excessive inflammation and risk of PE. Previous epidemiological studies indicate that PA may be useful in preventing PE. However, these studies have quantified PA based on recall of postpartum women and have not controlled for differences in their interpretations of amount, type or intensity of PA. But, controlling these variables in the research by using a laboratory-based PA intervention inflicts great difficulty. Translating the laboratory-based PA into a community-based program is problematic. Previous epidemiological studies indicate that PA may be useful in preventing PE. However, these studies have quantified PA based on recall of postpartum women and have not controlled for differences in their interpretations of amount, type or intensity of PA. But, controlling these variables in the research by using a laboratory-based PA intervention inflicts great difficulty. Translating the laboratory-based PA into a community-based program is problematic. PURPOSE: To determine the effect of standardized, community-based group PA on preventing PE. Method: A retrospective study was performed to determine the rates of PE among the 9,160 women who gave birth at Yale-New Haven Hospital (YNHH) during 2004-2005, and a 90 person subset of this group who performed prenatal PA in a standardized, community-based PA program for pregnant women. The PA program controls type and intensity of PA performed and has been offered in the community for 30 years. RESULTS: Total PE rate in 2004-2005 at YNHH was 7.8%. For the PA group, PE rate was 2.2%. Two women in the PA group were diagnosed with PE in the last month of pregnancy and delivered normal infants at term. No PE was seen in the PA group during the 2nd or early 3rd trimesters nor was there any prematurity in this group. CONCLUSION: Findings support the hypothesis that adequate physical activity in a standardized community-based group setting may be a non-pharmacological way to prevent PE.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.006 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.002 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".