Effects of Maternal Surgical Weight Loss in Mothers on Intergenerational Transmission of Obesity
Bibliographic record
Abstract
Previous studies have shown that obese women can transmit the susceptibility for obesity and its comorbidities to their offspring. Weight-loss surgery using biliopancreatic diversion (BPD) in severely obese women ameliorates type 2 diabetes, and corrects many features of the metabolic syndrome. These actions are associated with significant, long-term weight loss in these women. A pilot study showed that children born after their mother's BPD surgery had a significantly lower prevalence of obesity compared to siblings born before BDP surgery. This cross-sectional study investigated the effects of significant maternal weight loss associated with BDP surgery on the modification of obesity-related factors transmitted via the intrauterine environment and on the susceptibility of subsequent offspring to severe obesity. The study subjects were 49 mothers whose body weight loss (36% ± 1.8% body weight) had been maintained for 12 ± 0.8 years and their children aged 2.5 to 26 years born before (after maternal surgery [AMS] group, n = 57) and after (before maternal surgery [BMS] group, n = 54). Differences between the AMS and BMS groups in measures of anthropometry, and other metabolic parameters were studied. Multiple regression analysis was used to evaluate the independent contribution of individual factors. The birth weight of AMS children was lower compared to BMS children (2.9 ± 0.1 AMS vs. 3.3 ± 0.1 kg BMS, P = 0.003) and there was a reduced prevalence of macrosomia in neonates born after surgery (AMS:1.8% vs. BMS: 14.8%, P = 0.03) with no difference in underweight. In addition to these marked anthropometric changes, the following metabolic improvements were noted at follow-up in the AMS children in comparison with the BMS children. The prevalence of severe obesity was decreased 3-fold (11% vs. 35%, P = 0.004). All markers of insulin resistance, including insulin (P = 0.01), glucose (P = 0.008), and the homeostasis model assessment of insulin resistance index (P = 0.02) were decreased. The lipid profile was improved with decreases in the total cholesterol to high-density lipoprotein cholesterol ratio (P = 0.03) and increases in high-density lipoprotein cholesterol (P = 0.04). Levels of the inflammatory marker, C-reactive protein, were lower (P = 0.004). With respect to satiety-related factors, leptin was lower and ghrelin was higher (both P < 0.005). These findings demonstrate that prenatal weight control using BPD surgery in severely obese women can markedly lower the prevalence of severe obesity in AMS children through substantial reduction in several cardiometabolic markers transmitted via the intrauterine environment. This and similar interventions may have a long-term impact on the incidence of obesity in future generations.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".