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Record W2086799836 · doi:10.1159/000246247

Halogen Lamp Phototoxicity

2009· article· en· W2086799836 on OpenAlex
Ernest Bloom, James E. Cleaver, Robert M. Sayre, Howard I. Maïbach, J.R. Polansky

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueDermatology · 2009
Typearticle
Languageen
FieldMedicine
TopicSkin Protection and Aging
Canadian institutionsUniversité de Montréal
Fundersnot available
KeywordsPhototoxicityHalogen lampPyrimidine dimerSunlightPhotosensitivityIrradiationRadiationUltravioletErythemaHuman skinOpticsOptoelectronicsMaterials scienceChemistryDNA damageMedicineDermatologyBiologyDNAPhysics

Abstract

fetched live from OpenAlex

BACKGROUND: The radiation from quartz halogen light bulbs has been reported to cause erythema in humans and skin tumors in experimental animals. OBJECTIVE: The objective of this study was to determine the relative risk of injury to humans due to the radiation from these lamps. METHODS: We studied a 12-volt 50-watt quartz halogen lamp. We measured its ultraviolet output spectrum and the biological toxicity of its radiation by means of its pyrimidine dimer-inducing capability. RESULTS: At a 1-cm distance, the 254-nm light output of the lamp is 3 x 10(-7) W/cm2/nm. Solar radiation at this wavelength is undetectable on the earth's surface, i.e., less than 10(-12) W/cm2/nm. At 290 nm, the lamp output is approximately 3 x 10(-6) W/cm2/nm, 5,000 times greater than the summertime sun at 1 p.m. at sea level in Kuwait. The UVB and UVA output of the lamp is roughly similar to the solar output under these conditions. We also measured the pyrimidine dimer-forming potential of the lamps relative to the sun for the purpose of estimating the DNA toxicity of the lamps. At a 7-cm distance the lamp induces approximately 3.9 pyrimidine dimers/100,000 bp/min. This is approximately 4 times more rapid than that of the noontime summer sun in Michigan. CONCLUSIONS: We conclude that direct radiation from these lamps can cause damage to human skin, due to their UVC and UVB output. We estimate that the relative risk to keratinocyte DNA in human skin, in vivo, from exposure to the 50-watt halogen lamp at a distance of 7 cm is between 27 and 400% of the noontime summer sun in Michigan.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.144
Threshold uncertainty score0.265

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.281
Teacher spread0.267 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it