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Record W2087005537 · doi:10.1016/j.ajhg.2013.12.002

Immunochip Analysis Identifies Multiple Susceptibility Loci for Systemic Sclerosis

2014· article· en· W2087005537 on OpenAlexaff
Maureen D. Mayes, Lara Bossini‐Castillo, Olga Y. Gorlova, Jose‐Ezequiel Martín, Xiaodong Zhou, Wei V. Chen, Shervin Assassi, Filemon K. Tan, Frank C. Arnett, John D. Reveille, Sandra G. Guerra, María Teruel, F. David Carmona, Peter K. Gregersen, Annette T. Lee, Elena López‐Isac, Eguzkine Ochoa, Patrícia Carreira, Carmen Pilar Simeón‐Aznar, I. Castellví, Miguel Á. González‐Gay, Alexandra Zhernakova, Leonid Padyukov, Marta E. Alarcón‐Riquelme, Cisca Wijmenga, Matthew A. Brown, Lorenzo Beretta, Gabriela Riemekasten, Torsten Witte, Nicolas Hunzelmann, Alexander Kreuter, Jörg H. W. Distler, Alexandre E. Voskuyl, Annemie J. Schuerwegh, Roger Hesselstrand, Annica Nordin, Paolo Airó, Claudio Lunardi, Paul G. Shiels, Jacob M. van Laar, Ariane L. Herrick, Jane Worthington, Christopher P. Denton, Fredrick M. Wigley, Laura K. Hummers, John Varga, Monique Hinchcliff, Murray Baron, Marie Hudson, Janet Pope, Daniel E. Furst, Dinesh Khanna, Kristin Phillips, Elena Schiopu, Barbara Segal, Jerry A. Molitor, Richard M. Silver, Virginia Steen, Robert W. Simms, Robert Lafyatis, Barri J. Fessler, Tracy Frech, Firas Alkassab, Peter Docherty, Elżbieta Kamińska, Nader Khalidi, Henry Niall Jones, Janet Markland, David Robinson, Jasper Broen, Timothy R. D. J. Radstake, Carmen Fonseca, Bobby P. C. Koeleman, Javier Martı́n, Norberto Ortego‐Centeno, Raquel Ríos, José Luís Callejas-Rubio, Nuria Navarrete Navarrete, Rosa García Portales, María Teresa Camps, Antonio Fernández‐Nebro, María Francisca González‐Escribano, Julio Sánchez-Román, Francisco José García Hernández, María Jesús Castillo, M. Á. Aguirre, Inmaculada Gómez-Gracia, Benjamín Fernández‐Gutiérrez, Luis Rodríguez‐Rodríguez, Esther Vicente, José Luís Andreu, M. Fernández Castro, Paloma García de la Peña, Francisco Javier López-Longo, Lusiana Martínez, V Fonollosa, Gerard Espinosa, Carlos Tolosa, A. Pros, Mónica Rodríguez‐Carballeira, Manel Rubio Rivas, Vera Ortiz-Santamaría, Bernardino Díaz, Luis Trapiella, María del Carmen Freire, Adrián Sousa, María Victoria Egurbide, Patricia Fanlo Mateo, Luís Sáez-Comet, Federico Díaz‐González, Vanesa Hernández Hernández, E. Beltrán, José Andrés Román-Ivorra, Elena Grau, Juan José Alegre Sancho, Francisco J. Blanco, N. Oreiro, Luis Fernández Sueiro

Bibliographic record

VenueThe American Journal of Human Genetics · 2014
Typearticle
Languageen
FieldMedicine
TopicSystemic Sclerosis and Related Diseases
Canadian institutionsUniversity of ManitobaUniversity of SaskatchewanUniversity of AlbertaMcMaster UniversityAlberta Health ServicesMoncton HospitalWestern UniversityJewish General Hospital
FundersNational Center for Research ResourcesNational Center for Advancing Translational SciencesNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Institute of Allergy and Infectious DiseasesSociedad Española de ReumatologíaNational Institutes of HealthVersus ArthritisEuropean League Against Rheumatism
KeywordsLocus (genetics)Single-nucleotide polymorphismBiologyGeneticsHuman leukocyte antigenAlleleGenetic associationGeneGenotypeAntigen

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.013

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0020.001
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.031
GPT teacher head0.288
Teacher spread0.257 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations208
Published2014
Admission routes1
Has abstractno

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