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The relationship between cognitive impairment and cerebral blood flow changes after transient ischaemic attack

2013· article· en· W2087410718 on OpenAlex
Lin Wang, Jianping Jia, Liyong Wu

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

aboutThe title or abstract carries a Canadian signal from the geographic lexicon.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueNeurological Research · 2013
Typearticle
Languageen
FieldMedicine
TopicCerebrovascular and Carotid Artery Diseases
Canadian institutionsnot available
Fundersnot available
KeywordsMontreal Cognitive AssessmentMedicineCardiologyTranscranial DopplerInternal medicineCerebral blood flowVerbal fluency testCognitionCognitive impairmentBlood flowAudiologyNeuropsychologyPsychiatry

Abstract

fetched live from OpenAlex

OBJECTIVE: The associations between cognitive impairment following the initial onset of transient ischaemic attack (TIA) and the parameters of altered cerebral blood flow and high-sensitivity C-reactive protein (HsCRP) level are unclear. METHODS: A total of 97 first-time TIA patients aged 69.94 ± 4.02 years (38-75 years; M:F, 50:47) hospitalized between March 2010 and July 2011 were compared to 100 healthy control patients aged 66.56 ± 12.15 years (45-80 years; M:F, 60:40). Cognitive function was quantified by Montreal Cognitive Assessment (MoCA). Intracranial blood flow was measured using transcranial Doppler ultrasound, and HsCRP levels were assessed using the Spearman correlation coefficient. Relationships between both values and MoCA scores were examined. RESULTS: Transient ischaemic attack patients exhibited declined cognitive function manifested as impaired verbal fluency (97.93%), memory recall (91.75%), abstraction (84.53%), and visuospatial/executive abilities (79.38%). To a lesser degree, TIA patients also evidenced abnormalities in attention (50.52%), naming (20.62%), and orientation (20.62%). Furthermore, MoCA scores significantly correlated with high HsCRP levels and low vascular systolic peak velocities (P<0.001). Vascular systolic peak velocities were high in nine patients (9.23%) and low in 57 patients (58.76%). Thus, cognitive impairment was closely related to HsCRP levels and intracranial blood flow velocities. CONCLUSION: Post-TIA cognitive impairment may result from atherosclerosis and reduced blood flow to the brain. Cognitive impairment, transcranial Doppler-visualized changes, and elevated HsCRP levels are important diagnostic indicators of TIA. Markers provided by cognitive evaluation of TIA patients following the initial onset of TIA may allow clinicians to better predict and prevent adverse vascular events.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.014
Threshold uncertainty score0.405

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.098
GPT teacher head0.357
Teacher spread0.259 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it