Expression of tissue kallikrein mRNA in developing rat brains
Bibliographic record
Abstract
Immunoreactive kallikrein has been demonstrated in the neurons of both prenatal and adult rat brains. However, the preferential site is quite different between the prenatal and adult brains, i.e., the former is mainly in the nuclei, and the latter is in the cell bodies and processes. In this study, the intensity of kallikrein mRNA expression was investigated in prenatal and postnatal rat brains by reverse transcription polymerase chain reaction (RT-PCR). A marked progressive increase in kallikrein mRNA expression was observed during the prenatal and early postnatal stage, with the maximum level at postnatal days 0 and 1 (P0 to P1). This helps to explain the previous immunohistochemical findings in which a strong immuno-intensity of kallikrein in the neurons of prenatal and newborn rat brains was found as compared with adult rats. The function(s) of kallikrein expressed in the neurons in the developing stages is unclear, but the role(s) must be different from that of the adult because of the unequivocal difference in its location between them. It is thus possible that kallikrein has certain unknown important role(s) in the neuronal physiology acting on nuclear protein(s) in the developing stages, although the possibility of function via kinin receptors cannot be excluded at present.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".