<i>MGMT</i> METHYLATION IS A PROGNOSTIC BIOMARKER IN ELDERLY PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA
Bibliographic record
Abstract
Posterior reversible encephalopathy syndrome (PRES) is a reversible syndrome that presents with nausea and headache; altered consciousness; weakness; visual changes, including blurred vision or hemianopsia; seizures; and rarely coma. 1 MRI demonstrates vasogenic edema, generally bilateral, predominant in the posterior parietal, temporal, and occipital regions of the brain.Commonly associated with severe acute hypertension, PRES is associated with eclampsia, renal failure, electrolyte disorders, hypocholesterolemia, drug abuse, infections, autoimmune diseases, and immunosuppressive and chemotherapy. 1,2se report.A 39-year-old woman with untreated hypertension was admitted with headache, nausea, and vomiting.Three months before admission she had received radiation therapy for a single metastatic lesion in the odontoid process of a peritoneal leiomyosarcoma; 20 days before, she had completed a chemotherapy cycle with gemcitabine.She was drowsy with blurred vision.Blood pressure was 220/120 mm Hg and examination of optic fundus disclosed signs of hypertensive retinopathy.The examination was otherwise unremarkable, with flexor plantar responses.Blood tests were normal.Spectral attenuated inversion recovery MRI sequences showed large, confluent, bilateral, mostly symmetric hyperintense regions in the white matter of parietal and occipital lobes, cerebellar hemispheres, and right frontal lobe (fig- ure,A).Diffusion-weighted images demonstrated corresponding regions of increased water diffusivity; mild contrast enhancement was observed.MRI of the cervical spinal cord revealed a diffuse, central hyperintense signal on TSE T2-weighted sequences and mild swelling of the spinal cord; contrast enhancement was absent (figure, A).A diagnosis of PRES with spinal cord involvement was made.Treatment with spironolactone 100 mg/day and lisinopril 10 mg/day was started, blood
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".