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Record W2088499587 · doi:10.4161/cib.18058

Molecular control of compound Exocytosis

2012· article· en· W2088499587 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueCommunicative & Integrative Biology · 2012
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCellular transport and secretion
Canadian institutionsUniversity of Toronto
FundersNational Medical Research CouncilNational Health and Medical Research CouncilAustralian Research CouncilUniversity of Toronto
KeywordsExocytosisMunc-18VesicleVesicle fusionKiss-and-run fusionSecretory VesicleLipid bilayer fusionCell biologySNAP25Secretory pathwayBiologyChemistrySecretionSynaptic vesicleMembraneBiochemistryGolgi apparatus

Abstract

fetched live from OpenAlex

Exocytosis is the process of fusion of a membrane-bound vesicle with the cell membrane and subsequent release of the vesicle content to the outside. It is now widely accepted that SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) proteins are key components in the molecular machinery of exocytosis. SNARE proteins on the vesicle membrane selectively form complexes with specific SNAREs on the cell membrane. In a variant of exocytosis, called compound exocytosis, secretory vesicles still fuse with the cell membrane but vesicle-to-vesicle fusion enhances secretory output. Two types of compound exocytosis occur, either vesicles fuse with each other and then fuse with the cell membrane, or a vesicle fuses with the cell membrane and then becomes a target for further vesicles to fuse with it. It is expected that SNAREs are important for vesicle-to-vesicle fusion but the mechanism(s) that control these processes is unknown. In our recent paper (Behrendorff et al. 2011) we provide evidence that VAMP8 (a Q-SNARE) is essential in regulating compound exocytosis. Here we discuss the implications of our findings with reference to a new model for the control of vesicle-to-vesicle fusion.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.175
Threshold uncertainty score0.642

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.019
GPT teacher head0.281
Teacher spread0.262 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it